This paper investigates the relationship between external debt, population growth, and inflation with unemployment in 26 developing countries. The study uses data from 2010 to 2021 and panel data models (fixed, random, and pooled) to analyze the relationship between the variables. Results show that external debt has a significant and positive impact on unemployment across all three models. Similarly, GDP growth has a reducing and significant impact on the unemployment rate, which shows high employment elasticity of growth in the case (...) of these 26 developing countries. Another important finding of the study is that foreign direct investment, inflation, and population growth have a non-significant impact on unemployment. The paper suggests robust macroeconomic policies and effective debt management in these developing countries to address the issue of unemployment. (shrink)

Abstract: The use of the technology in the way of teaching and learning in the higher educational institutions sustained a significant position during the pandemic emergency in Pakistan and across the world to continue the educational activities. The extant study investigates the pedagogical challenges in which proposed factors used to discover the intention of the users in the form of their ease of the technological use and assessing the social influence of people regarding the innovative digital adoption in the online (...) learning atmosphere. This research inculcates the antecedents like perceived ease of use (PEOU) social influence (SI), satisfaction (S), and intention to use (ITU) to chart out the perception of the wireless based educational activities during the COVID-19 outbreak in the country and it aims to produce an empirical analysis of the easiness and social influence of users to accept the newly adopted technology and calculating the Web based pedagogical challenges via interpreting the users’ intention. For the data analysis 216 questionnaires have been collected from the teacher and students among three public universities in Sindh and the existing review develops a proposed conceptual framework model to meet the objectives of the study. In the way of the interpretation of data SPSS version 24 was brought in use and the testes of the hypotheses were carried out by means of regression and correlations. The research follows the limitation to meet the quantitative research methodology, teachers’ web based easiness and social feedback to deliver the online teaching and the recommendations urge to discover a research by using different factors. (shrink)

Conceptual metaphors have received much attention in research on discourse about infectious diseases in recent years. Most studies found that conceptual metaphors of war dominate media discourse about disease. Similarly, a great deal of research has been undertaken on the new coronavirus, i.e., COVID-19, especially in the English news discourse as opposed to other languages. The present study, in contrast, analyses the conceptual metaphors used in COVID-19 discourse in French-language newspapers. The study explored the linguistic metaphors used in COVID-19 discourse (...) in these newspapers and conceptual metaphors that underlie and motivate them, using a conceptual metaphor theory framework (CMT). Therefore, two North African French-language newspapers, namely Libération, published in Morocco, and La Presse de Tunisie, published in Tunisia, formed the corpus of the current study. The results showed that the most frequent framing of COVID-19 was in terms of WAR, followed by DISASTER and KILLER, respectively. (shrink)

Abstract: Adoption of digital system becomes an innovative revolution to replace the tradition work into scientific means. Electronic government is the use of technology in which particular wireless based application sustains the provision of online interconnectivity in the way to convey a speedy service delivery and materialize an easy accessibility of users via government portal. Moreover, the vitality of e-government has been recognized in the contemporary era of science and technology across the world. The chief aim of this study to (...) represent a literature of an electronic government use in a conceptual means in which proposed determinants as PEOU, PU, TIEG, SI, and ITU envisage the intention of the users’ online services of government in a Pakistan perspective. In the existing literature all constructs of the proposed model possess an effect on the intention to use e - government and the theoretical approach encompasses the TAM and UTAUT model to assist the technological adopti on of the employee's use of the innovative system in an organization. However, Pakistan has been ranked low in the e-government development index that seems the backwardness of the e-government adaptation in the country that is recognized as the dire need to be adjusted with public sectors to sustain an effective and efficient service delivery. It seems the poor literacy rate an d financial constraints are serious obstacles for adopting e-government technology in the working atmosphere of the diverse public sector organizations. Keywords: Electronic government, Perceived usefulness, Obstacles, Recommendations, Intention to use. (shrink)

West Nile virus (WNV) is a mosquito-borne flavivirus that was first identified in 1937 in the West Nile district of Uganda. The virus is now widely distributed throughout the world and is considered a significant public health concern. WNV is primarily transmitted to humans through the bite of infected mosquitoes, with birds serving as the primary reservoir host. Most people infected with WNV will not experience any symptoms, but approximately 1 in 5 will develop a fever, and a smaller percentage (...) may develop more severe symptoms such as meningitis or encephalitis. There is no specific treatment for WNV infection, and prevention efforts focus on mosquito control measures and personal protective measures to avoid mosquito bites. While WNV is not typically considered a major threat to human health, outbreaks have occurred sporadically in various parts of the world, and ongoing surveillance and research are necessary to better understand and control the virus. Objectives: This paper will solve the problems of treatment of West Nile virus (WNV) through correct diagnosis and treatment. Methods: In this research, we provide an expert system for the diagnosis of West Nile virus (WNV) which will help doctors to explore everything related to the problems of West Nile virus (WNV). We look forward to providing simplified answers to West Nile virus (WNV). (shrink)

Nomophobia (no-mobile-phone phobia) is the fear and anxiety of being without a mobile phone. This study pioneers the investigation of nomophobia in Afghanistan using the Nomophobia Questionnaire (NMP-Q), addressing a crucial gap in the field. We collected statistical data from 754 undergraduate medical students, comprising men (56.50 %) and women (43.50 %), and analyzed the dimensions of nomophobia. While results revealed that all but two participants were nomophobic, they identified three significant dimensions affecting the level of nomophobia among participants: (a) (...) gender, (b) age, and (c) marital status. The study's contributions are precious, given the peculiarity of Afghan political turmoil, security, and human rights issues, especially for women. For example, the study's data collection was abruptly halted in December 2022 due to the Taliban regime's decision to make it illegal for women to enroll in universities as students. Therefore, while examining the characteristics of nomophobia across societies is imperative, it is also vital to investigate what is true of one society, Afghanistan, at one point in time and space. The study concludes by emphasizing the need to broaden participants' scope in future studies to better understand the prevalence of nomophobia across broader societal contexts and forces. (shrink)

According to the received view the later Wittgenstein subscribed to the thesis that speaking a language requires being guided by rules (thesis RG). In this paper we question the received view. On its most intuitive reading, we argue, (RG) is very much at odds with central tenets of the later Wittgenstein. Giving up on this reading, however, threatens to deprive the notion of rule-following of any real substance. Consequently, the rule-following considerations cannot charitably be read as a deep and subtle (...) defense of (RG) against the threat of paradox, as proponents of the received view are wont to do. Instead, we argue, the rule-following considerations provide Wittgenstein's deep and subtle reasons for rejecting the very idea that speaking a language involves rule-guidance. Although Wittgenstein subscribed to (RG) during his middle period writings, his later remarks on rules, far from being a clarification and elaboration of his earlier views, are directed against the claim of the middle period that speaking a language is an essentially rule-guided activity. (shrink)

Despite the large number of studies conducted on polysemy, they mostly compare the different methods and techniques to learn a language and establish the extent to which particular sense relations facilitate the learning of second language vocabulary. To our best knowledge, no research has been conducted to determine whether or not polysemy is emphasized in non-native English textbooks. The objective of the present research was to determine the degree to which polysemy is incorporated in English textbooks. Thus, the research question (...) guiding the current study is: To what extent is polysemy incorporated in non-native English textbooks? The study is corpus-based research that used a data set of 500 words, i.e., 250 words from each of the two books, utilizing the Sketch Engine word list tool and concordance. The polysemy of the resulting words in the concordance lines generated was semantically annotated manually using WordNet and English dictionaries. The results indicated that polysemy is barely stressed in the textbooks under investigation. The study’s results have substantial implications for polysemy in particular and second or foreign language teaching in general. (shrink)

The study investigated the impact of parental income on students' academic performance in secondary schools in Kitswamba and Rugendabara-Kikongo town councils in Kasese District. A cross-sectional research design was used, with data collected from 286 students and five head teachers. The findings showed that family income significantly influenced students' academic performance. The findings have implications for parents, teachers, policymakers, and administrators in the education sector, emphasizing the importance of parental income in determining academic success.

Studies on difficulties in understanding scientific terms have shown that the problem is more serious among non-Western learners. The main reasons for this are the learners' pre-existing knowledge of scientific terms, their native language incommensurability with Western languages, and the polysemy of the words used to denote scientific concepts. The current study is an analysis of the conceptualisation of scientific concepts in two culturally different languages, i.e. Arabic and French, which represent a non-Western language and a Western language respectively. Physics (...) concepts which are considered as some of the most challenging concepts for non-Western languages (Loo 2005; Aranador 2005) were selected for analysis. To this end, the terms that refer to two physics concepts, "weight" and "mass" in Arabic وَزْن (wazn) and كُتْلَة (kutla) and in French poids and masse were semantically analysed. The analysis of the concepts in both languages is informed by the prototype theory by Rosch (1973; 1975), idealised cognitive models (ICMs) by Lakoff (1987), and conceptual metaphor and conceptual metonymy by Lakoff and Johnson (2003). The data for analysis were retrieved from two comparable Arabic and French corpora, namely the ArabiCorpus and the Concordancier-Corpus Français. The results suggest that there are both similarities and differences between the Arabic and French concepts in terms of meanings, prototypes, and metaphorical as well as metonymic semantic extensions. These findings support the argument that the human conceptual system is related to our environmental and cultural experiences and also importantly, validate previous claims on the need for educators to be cognizant of the culturally relevant meanings of scientific words found in everyday language that may impede learners' understanding of scientific concepts. (shrink)

For various historical, political as well as economic reasons, the English language is favoured as the universal language of science over other languages including French and German (Tardy, 2004). This naturally entails that students who are conversant in English have an advantage over those who are not in the acquisition of scientific knowledge. In relation to this, research on the misunderstanding of scientific terms in different languages shows that students who are speakers of non-western languages in particular face difficulties in (...) conceptualising scientific concepts. There is evidence to suggest that these students’ pre-existing knowledge about scientific terms and the polysemous nature of such terms are factors that influence their conceptualisation of the terms. This finding is the motivation behind the present cognitive linguistic study of the term temperature and its equivalent in Arabic, the compound دَرَجَةُ الحَرَارَة (darajatu al-ḥarara). Using a cognitive framework, namely Lakoff’s Idealised Cognitive Models (ICMs), the study analyses the conceptual similarities as well as differences between the terms. The study also analyses the English term heat as the second free morpheme of the compound دَرَجَةُ الحَرَارَة is الحَرَارَة which is the Arabic rendering of heat. The meanings and different uses of the terms are examined to analyse the ICMs that are evoked in each language. The results of the analysis reveal that the ICMs of English and Arabic terms under study overlap, and interestingly, also differ. (shrink)

Abstract- Performance is the primary function of human resource management and it becomes life line of an organizational success. The performance gap is extremely highly detrimental towards an organizational success. Prevailing study is concerned with the affecting factors of teachers’ performance in which administrative bureaucratization, unequal provision of opportunities, social status and incentives gap loss the vitality and tempo of performance in classroom atmosphere. Emergence of complexities in teachers’ life allow to a complex instructional approach that gives birth to a (...) problematic classroom and breach the center of attention and rejects a sound learning environment. The exiting study is concerned with an investigation of teachers hampering antecedents to lower down their performance by an empirical means on the basis of survey research and quantitative approach. In data collection 350 questionnaires were distributed and respondents’ feedback remained 243 (69.4%) and population was investigated on the basis of affecting antecedents towards teachers’ performance at middle and higher secondary level and random sampling technique was applied. Five points Likert scale tool was used to collect the data and analysis was carried out via SPSS version 24. Lowering performance hampers the education transmission to coming generation and it results to professional dissatisfaction and unfriendliness to class room environment. The reflexive attitudes of teacher relate to boredom, monotony and ineffective delivery of teaching objectives and scarcity of interest prevail and feelings like deprivation to students and coworkers to become a reason to discontent and discomfort towards the organization. (shrink)

Abstract- This study's objective is to examine how people perceive about the technology. Use by public employees via interpreting the intentional approach of users in Pakistan context. The prevailing research inculcates the behavioral constructs such as "perceived usefulness" (PU), " Trust in technology (TIT), "intention to utilize (ITU)," and "perceived ease of use" (PEOU), together with other relevant considerations, affect how an employee feels about their employer's tendency to utilize modern technology in the public sector. TAM and Technology Acceptance Model (...) and the Unified Theory of Acceptance (UTAUT) are to be applied respectively. Use of Technology is to be incorporated into its theoretical underpinnings, both of which are helpful in determining an employee's intent with regard to the usage of e-government services. The proposed conceptual framework model was empirically tested by using a sampling method to collect 243 responses out of a total of 400 survey items that were distributed among public employees. Data were gathered using the suggested survey questions, which analyzed by using SPSS version 24 and included hypothesis tests validated by multiple regressions and pearson's correlation. According to the findings of the research that was conducted, all of the proposed factors have a positive and significant relationship with the dependent construct intention to use (ITU) e-Government.\and the present research also encircled limitation, practical implications and future direction. (shrink)

Abstract: Pakistan has been affected by the outbreak of COVID-19 and government took effective initiatives to deal the prevailing situation in a possible means. Likely, in the education sector government adopted online learning process across the country and adapted the electronic learning environment in order to seize the spread the pandemic. This study investigates the perception of students regarding their adoption of digital assessment during COVID-19 outbreak to evaluate their educational activities. Digital assessment is also considered as electronic assessment in (...) which students educational evaluation is materialized to encircle the online examination, assignment submission, and calculation of candidate's study progress. The aim of this study is to provide an empirical investigation of online via discovering the intentional approach of electronic learning users in Pakistan during COVID-19 outbreak. The interpretation of the questionnaires of student and teachers is based on the data that has been collected from the public universities in Sindh. For investigating users of digital assessment behavioral determinants were applied in which (PEOU, PU, SI and OA) measured with and intention to use digital assessment (ITDA) and proposed determinants users intention during the outbreak of the pandemic. The prevailing survey study follows the conceptual proposed framework model that assists to investigate the users' perception towards students' online assessment. For the data analysis 413 questionnaires were distributed and 286 respondents feedback restored by filling the research items online means. Moreover, SPSS version 24 was adopted and hypothesis tested through egressions and correlations. The research is confined to higher education and online learning system in Pakistan needs to be examined at higher secondary and country level. (shrink)

Abstract- Administrative corruption has a long history in Pakistan which affected each public institution since its inception. Good governance in Pakistan never took a sigh due to Bribery in public sector and versatile Miraculous of Corruption in Public Administration. Administrative corruption possesses a multidimensional and complex phenomenon that has been created by numerous factors to affect at a wide range and each segment of society to be exhibited in a diversity of roles and traits. This study is considering significance of (...) the subject and discovers the respondents’ response and identifies the causes and consequence of this dilemma. The current research attempts to measure the administrative corruption in education sector in Sindh and it also encompasses the implications on education professionals’ performance and their profession. For data analysis, sampling was derived from teaching, and non-teaching staff in education sector to construct open ended questionnaires and respondents’ privacy was ensured to fill the survey items. For data collection, 203 respondents feedback was secured and analysis was carried out by means of SPSS. The self-constructed questionnaires were used and the findings of the study support the administrative corruption in education sector was faced by respondents in the form of agent and non-agent based corruption in the treasury and concerned offices in the education department. In this way, agent based corruption and non-agent based corruption maintain positive and significant relation with Administrative Corruption. Moreover, prevailing study also encircles implications and recommendation, limitations, and future direction. Keywords: Administrative Corruption, Education Sector, Administrative System, Bribery. (shrink)

Abstract: This study aims to evaluate the utilization of ICT in education administration and management in a Pakistan context during the pandemic outbreak. Adoption of information and communication technologies (ICTs) has digitalized the learning process where education organizations were administrated by means of wireless-based instructions, electronic pedagogy, and online assessment in order to continue the educational activities while the government halted the physical appearance in education institutions. Data collection has been carried by three public universities in which teachers and general (...) administration of these institutions participated to discover their intention to use the assigned technology to administrate organizations’ policies in the way to disseminate the respective service delivery. Survey questionnaires were used, and 178 respondents’ feedback was secured to analyze the study that was carried out via SPSS version 24 and validation OF hypotheses measured by means of regressions and correlations. Moreover, proposed factors like intention to use, perceived ease of ease, perceived usefulness, social influence, and Users’ expectations were used. A theoretical approach was inculcated to encircle the UTAUT and TAM model to determine the adoption of the innovative system education management during the pandemic outbreak in the country. (shrink)

ABSTRACT For learning any language, motivation plays a vital role. This study aims to investigate collegiate students’ predictive motivational factors toward students’ attitude toward learning English as secondary language. This is a cross-sectional study in which questionnaire was adapted from the existing literature for data collection. For this quantitative study data were collected from two government degree colleges of Larkana. Total 400 questionnaires were randomly distributed among intermediate students both boys and girls, out of that 247 were returned. Data were (...) analyzed using statistical packages for social sciences (SPSS) version 24. Initially, data were cleaned by identifying missing values and outliers. Study hypotheses were examined using Multiple Regression Analysis (MRA). The findings of this study revealed that instrumental motivation and parental encouragement (independent variables) have positive and significant relationship with attitude toward learning English. However, one variable i.e. integrative motivation was not found as a significant and positive predictor of the dependent variable. Like any study, this study also possesses few limitations, such as sample size, time horizon, and context of the study. In the end, future directions are given for further exploration. (shrink)

Abstract: The ostrich industry in Egypt is an emerging economic activity, which has spread especially since 1998 on the scale of small and medium farms, some farms and large companies. The study deals with the study of ostriches through an analytical study in economic geography. It deals with several axes including: Ostrich industry in Egypt and ostrich species through the geographical study of ostrich production: in view of the geographical distribution of ostrich farms in ancient Egypt and recent times, Ostrich (...) and hatchery (Incubation), nests and egg laying, and production systems used in farms designated for ostrich. The subject of ostrich farms deals with the types of farms, nutrition, products of ostriches, and the production of meat, leather and feathers of ostriches, along with other products such as fat, eggs, eyes and ostrich oil. The research also deals with diseases affecting the ostriches and treatment and veterinary fortifications. Economic feasibility and the most important problems of ostrich farming in Egypt. (shrink)

Throughout history, Eurasia has been central to relations between Europe and Asia. It has been the crossroads of civilizations, contributing to the cultural and ethnic hybridity of the region. However, after the fall of the Ottoman Empire and later the Soviet Union in the twentieth century, Eurasia lost its geostrategic importance in the US-led liberal world order. In the 1920s, a group of Russian emigres described the cultural and ethnic ties among the communities living across the vast Eurasian steppes as (...) Eurasianism. Eurasianists divide the world into two opposing forces with Eurasianism including Russia and the European states favoring integration with it and Atlanticism including the US and European countries supporting an American-led Atlantic order. Today, Russia is an important revisionist power in Eurasia, with huge stakes in the global order and the capability to help forge new relationships in the region. (shrink)

Since the disintegration of the USSR Eurasia has gained a new geopolitical and strategic significance. Fifteen Countries emerged as a result of disintegration, among which only the Russian Federation was the successor state. The post-soviet era especially the era of the 1990s was a political and economic trauma for the Russian Federation and the post-soviet space. But Eurasianists were well aware of the American unilateralism and American ‘Grand Chessboard strategy” that was solely aimed at encircling Russian geography. With these concerns, (...) the Eurasianists advised the Russian political and military elites to initiate the Eurasian Union Project. This paper briefly sketches the Russian historical Eurasian dream, which deeply rooted in Russian imperial history, and discusses the importance of Eurasian philosophy for the political and economic stability of Russia-Eurasia. The paper also illustrates the challenges and opportunities for Eurasian integration and for the establishment of multipolar world order. Moreover, the paper also briefly outlines the geopolitical rationale behind the Eurasian project as a key objective of contemporary Russian foreign policy and geopolitics. (shrink)

Being a widely translated piece of work, the Daodejing becomes vulnerable to 'translation errors', which fail to bring across the nuances in certain parts of the text. This thus leads to the existing argument that the Daodejing seems to portray some form of linguistic skepticism, through the presence of differing interpretations of the Dao and the moral truth of wuwei (无为) (non-action). Furthermore, given that the text is widely used as a moral guide, there is a problem. It now seems (...) that the text perpetuates moral skepticism as well. In this paper, I analyse the question of whether linguistic skepticism in the Daodejing does bring about moral skepticism, and argue that it is the case; that moral skepticism does indeed follow from linguistic skepticism. The hope through this discussion is to call for a universal address of the presence of linguistic skepticism in the Daodejing and how it perpetuates moral skepticism, for this topic is still rather novel in the community, and open up further discussion. (shrink)

The title of the book was chosen due to inspiration from Nietzsche’s famous book ‘Beyond good and Evil’, which has marked an unprecedented turning point in the history of philosophy. Hence, the book titled ‘Beyond Civilization and History’ is intended to outline the politico-historical debate, since the dawn of the 20th century. The discussion in the book will cover pre-modern, modern and post-modern discourse of the history of civilizations. The debate mainly focuses on the modernist and post-modernist historical context especially (...) surrounding the writings of Oswald Spengler, Norman Angell, Arnold J. Toynbee, and Alexander Dugin. (shrink)

We consider how an epistemic network might self-assemble from the ritualization of the individual decisions of simple heterogeneous agents. In such evolved social networks, inquirers may be significantly more successful than they could be investigating nature on their own. The evolved network may also dramatically lower the epistemic risk faced by even the most talented inquirers. We consider networks that self-assemble in the context of both perfect and imperfect communication and compare the behaviour of inquirers in each. This provides a (...) step in bringing together two new and developing research programs, the theory of self-assembling games and the theory of network epistemology. (shrink)

We present two defeasible logics of norm-propositions (statements about norms) that (i) consistently allow for the possibility of normative gaps and normative conflicts, and (ii) map each premise set to a sufficiently rich consequence set. In order to meet (i), we define the logic LNP, a conflict- and gap-tolerant logic of norm-propositions capable of formalizing both normative conflicts and normative gaps within the object language. Next, we strengthen LNP within the adaptive logic framework for non-monotonic reasoning in order to meet (...) (ii). This results in the adaptive logics LNPr and LNPm, which interpret a given set of premises in such a way that normative conflicts and normative gaps are avoided ‘whenever possible’. LNPr and LNPm are equipped with a preferential semantics and a dynamic proof theory. (shrink)

Choice experiment (CE) is a questionnaire based method that the accuracy of research questionnaire determines the validity of the research outcomes. Attribute selection has a prime importance in every CE studies. If respondents do not understand or do not have preference for a certain attribute, the attribute non-attendance problem might happen that biases overall results of the research. Qualitative approaches such as literature review, focus group discussion, and in depth discussion commonly applied in CE researches. However, especially in the developing (...) countries context where ethnical and cultural diversity is a challenge in conducting survey based questionnaires, qualitative methods are not sufficient in selecting attributes. Present study investigates the application of relative importance index (RII) in respondents¡¯ preference for attributes in a modal shift study in Klang Valley, Malaysia. The 5 point Likert scale questions were employed to enhance respondents¡¯ preferences for initial 24 selected attributes. The results of this study showed that from 24 pre-selected attributes, only 18 of them had RII>0.5 and could be included in the final CE design. The results of this study could help researchers to control for unobserved problems in selecting the attributes which could not be discovered through qualitative approaches. -/- . (shrink)

Di er ci Qimeng (The second Enlightenment), by Wang Zhihe and Fan Meijun, is a timely book in Chinese about constructing a philosophical and practical way to contend with China's postmodernization. It combines Whitehead's process philosophy with a focus on Chinese modernity in order to map out a desirable postmodern society. It addresses the problem on several dimensions from policy making to basic value systems. The range of themes can be seen from the topics of the book's twelve chapters: (1) (...) Reverence for Land—Toward a Constructive Postmodern Agriculture; (2) Becoming Fully Human—Toward a Postmodern Organic Education; (3) Survival of the Harmonious-Toward a Constructive Postmodern Harmonious Culture; (4) Beauty .. (shrink)

Den filosofiske position konsekventialisme er ofte genstand for debat i filosofikredse, men alt for hyppigt opstår der misforståelser blandt de involverede, fordi de ikke er eksplicitte, hvad grundantagelser og væsentlige distinktioner angår. Denne korte artikel vil give en approksimation af, hvad der forstås ved konsekventialisme på et generisk niveau. Målet med artiklen er at klargøre nogle af de grundantagelser og distinktioner, som konsekventialister ofte benytter i deres teoridannelse, og som bør holdes for øje i ønsket om en frugtbar debat.

In debates over life and death it is often said that one should err on the side of caution—that is, on the side of life. In light of the recent case of Terri Schiavo, it is explained how the “err-on-the-side-of-life” argument proceeds, and an objection to it is offered.

Saturated free fatty acids-induced hepatocyte lipoapoptosis plays a pivotal role in non-alcoholic steatohepatitis. Theactivation of endoplasmic reticulum (ER) stress isinvolved in hepatocyte lipoapoptosis induced by thesaturated free fatty acidpalmitate (PA). However, the underlying mechanismsof the role of ER stress in hepatocyte lipoapoptosis remain largely unclear.In this study, we showed that PA and tunicamycin (Tun), a classic ER stress inducer, resulted in differential activation of ERstress pathways. Our data revealed that PA inducedchronic and persistent ER stress response, but Tuninduced acute and (...) transientER stress response. Compared with Tun treatment, PAinduced much lower glucose-regulated protein 78 (GRP78), a centralregulator of ER homeostasis, accumulation. It is noteworthy that GRP78 over-expression not only inhibited PA-induced ERstress but also decreased PA-induced apoptosis. Taken together, our data suggest that the differentialactivation of ER stresssignal plays an important role in PA-induced hepatocyte lipoapoptosis. More detailed studies on the mechanisms of PA inrepressing the accumulation of GRP78 will contribute to the understanding of molecular mechanisms of lipoapoptosis. (shrink)

Saturated free fatty acids-induced hepatocyte lipoapoptosis plays a pivotal role in non-alcoholic steatohepatitis. Theactivation of endoplasmic reticulum (ER) stress isinvolved in hepatocyte lipoapoptosis induced by thesaturated free fatty acidpalmitate (PA). However, the underlying mechanismsof the role of ER stress in hepatocyte lipoapoptosis remain largely unclear.In this study, we showed that PA and tunicamycin (Tun), a classic ER stress inducer, resulted in differential activation of ERstress pathways. Our data revealed that PA inducedchronic and persistent ER stress response, but Tuninduced acute and (...) transientER stress response. (shrink)

Ebû Bekir Zekeriyyâ er-Râzî’nin Felsefî Görüşleri: İlâhiyyât (Metafizik) ve Tabîiyyât (Doğa Felsefesi), Turgut Akyüz, İstanbul: Ravza Yayınları, 2017, 255 s.

Edebiyat, özellikle roman, toplum için bir ayna gibidir. Roman, hikâye ve şiir gibi edebî eserler, kişisel üretimlerin yanı sıra dönemin sosyal, ekonomik ve siyasi meselelerini de yansıtır. Bu nedenle edebi eserler de sosyolojik kaynak olarak kabul edilebilir. 19. Ve 20. yüzyıl Türk ve Rus edebiyatı, büyük yazarların tüm dünyada ün kazandığı yüzyıldır. 19. Ve 20. yüzyılda Türk ve Rus edebiyatının zirvesi kabul edilen isimler toplumsal konulara kayıtsız kalmamalarının yanı sıra Türk ve Rus toplumunun modernleşme sürecini de eserlerinde yorumlamışlardır. Entelektüeller genellikle (...) bu merkezlerde yoğunlaştıkça, düşünce, bilim ve edebiyat siyaseti de bu merkezlerde yoğunlaşmıştır. Dönemin en önemli dergi ve gazeteleri bu edebiyatçılarla ilgili basılıp dağıtılıyordu. Tarih boyunca siyasi iktidar, kendi amaçlarına hizmet etmek, rejimlerini korumak ve toplumsal hegemonyalarını sağlamlaştırmak için örgütlü aydınlara ihtiyaç duymuştur. Yüzyıllardır enformasyonu tekelleştiren aydınlar, kültürel sermayelerini çoğu zaman kendi sınıfsal amaçları için kullanarak, bazen siyasi iktidarla çatışan, bazen de uzlaşmaya varan ideolojiler üretmişlerdir. Bu çatışma ve uzlaşma ekseninde, aydının idari yapıya karşı tutumu, yönetici sınıfın statükoyu koruma çabası, yerel ve evrensel sorunlar, iktidarla ilişkisi tanımlanmaktadır. Bu bakımdan aydınların her toplumdaki konumu ve rolü farklıdır. Aslında Batı toplumlarında muhalif kimliği ve iktidar eleştirisi ile öne çıkan entelektüelin işlevi, Batı dışı toplumlarda iktidarın yönetsel işlevlerini yerine getirmek ve bilgisiyle iktidarı meşrulaştırmaktır. Klasik Osmanlı İmparatorluğu'nda iktidarın (devletin) "koruma", Tanzimat döneminde ise "kurtarma" (diriliş) döneminde Türk aydınlarının, tarihsel, toplumsal ve sınıfsal kategorilerdeki entelektüellerin işlevleri söz konusudur. Bu çalışmada ele alınan Türk ve Rus aydınların kısaca bilgileri verilmiştir. (shrink)

Als Plato de hedendaagse academie zou aanschouwen, zou hij niet alleen stomverbaasd zijn over de massificatie en de byzantijnse bureaucratie, maar gezien het ethische doel van de universiteit zou hij ook reden hebben om bezorgd te zijn.

In §21 of Grundgesetze der Arithmetik asks us to consider the forms: a a2 = 4 and a a > 0 and notices that they can be obtained from a φ(a) by replacing the function-name placeholder φ(ξ) by names for the functions ξ2 = 4 and ξ > 0 (and the placeholder cannot be replaced by names of objects or of functions of 2 arguments).

Johann Georg Hamann's "Metakritik über den Purismum der Vernunft" begins with an allusion to Hume's endorsement of Berkeley's rejection of abstract ideas. On the basis of a close examination of the text of the Metakritik, I show that Hamann's overall point is that Kant cannot, or anyway does not, justify the relation of his own linguistic framework to natural language. Thus the Critique cannot meet its own standard for critical self-examination.

The paper discusses the epistemological basis for how you know what you are doing intentionally (and why). In particular, it challenges and ulimately rejects the claim made by Sarah K. Paul that such knowledge has an inferential basis.

Taking as its starting point that morality does not exist (moral error theory), this chapter tries to persuade the reader to eradicate it from her psyche as well (moral abolitionism). It is argued further that the most effective way to rid oneself (and society) of moralist attitudes would be to eliminate moralist vocabulary and manners of speaking and, indeed, to the greatest degree practicable, all normative vocabularies and manners of speaking. This is because moralism lies deep and pervasively in the (...) human psyche and hence requires a special effort to root it out. A particular problem is how to eradicate moralism from the abolitionist project itself. For the natural way to think about it is as advocating that we ought to be amoral or that being amoral would make this a better world. But these are themselves moralist ways of thinking. This chapter seeks to obviate this problem, as well as fill the void left by morality’s elimination, by defending a positive ethics of desire (desirism). (shrink)

This intra-view explores a number of productive junctions between contemporary Deleuzoguattarian and new materialist praxes via a series of questions and provocations. Productive tensions are explored via questions of epistemological, ontological, ethical, and political intra-sections as well as notions of difference, transversal contamination, ecosophical practices, diffraction, and, lastly, schizoanalysis. Various irruptions around biophilosophy, transduction, becomology, cartography, power relations, hyperobjects as events, individuation, as well as dyschronia and disorientation, take the discussion further into the wild pedagogical spaces that both praxes have (...) in common. -/- . (shrink)

In the history of European philosophy and science, René Descartes is considered an author of a methodology of radical doubt, meditation, and the conception that explains the cause of human errors. But the course on internalization, knowledge of one's own Self, methodology of searching foundation of knowledge and conception of perfect reason have been formed already in the times of a Late Antiquity, particular by Augustine in his works “Soliloquies” and “Confession”, Boethius’s “The Consolation of Philosophy” and was continued in (...) the New age by Loyola’s “Spiritual exercises” and Teresa of Avila’s “The Interior Castle”. Therefore, Descartes could be rightfully considered rather the brilliant inheritor of this tradition than pioneer. To this chain of philosophers and theologians who were forerunners of Descartes’s theory of Radical doubt and especially problem of the source of human errors worth to add a new name – Hadewijch, the representative of medieval Dutch vernacular theology and her works “Visions” along with “Letters”. Precisely her point of view on cause of human errors, very close to the explanation have been given by Descartes in his IV Meditation. The aim of the research is to demonstrate common positions of Descartes’s and Hadewijch’s explanation of the nature of the errors. (shrink)

Post colonialism is often understood to be a period of time after colonialism and post-colonial literature is usually characterized by its opposition to the colonial discourse. However, any literature that expresses an opposition to colonialism, even if it is written during a colonial period, may be defined as postcolonial literature, primarily due to its oppositional nature. From this point of view, novels like ‘Kankabati’, ‘Nildarpan’, ‘Bolmik’, ‘Tabubihanga’, ‘Aranyer Adhikar’, ‘Droupadi’, ‘Akasher Niche Manus’, and Mohakaler Rather Ghora’ have been discussed in (...) this paper. The paper also highlights that the so-called renaissance and modernity in Bengali Literature took place under the imposed structure of an English modernity. Perceived in this light, a new dimension of Bengali novels could be found, where the plights of marginalized sections are being highlighted. The paper is analytical in nature construed with the help of Primary and Secondary data. (shrink)

In the early twentieth century Walter Benjamin introduced the idea of epochal and ongoing progression in interaction between mind and the built environment. Since early antiquity, the present study suggests, Benjamin’s notion has been manifest in metaphors of gender in city-form, whereby edifices and urban voids have represented masculinity and femininity, respectively. At the onset of interaction between mind and the built environment are prehistoric myths related to the human body and to the sky. During antiquity gender projection can be (...) detected in western perceptions linking natural and built environments, commencing with Plato’s Atlantis and his Myth of Er, and later as a likely import of the Chinese yin-yang mythology. Culminating with the Age of Discovery, alongside advances in experiential awareness of the Earth’s sphericity, respective feminine and masculine earmarks can be detected in early modern perspicacity of the Earth’s southern and northern hemispheres. Our conceptions of natural and built environments inherently continue to contain gender traits. Yet urban voids, as the feminine face of city-form, have been severely understated in the built environment. Through design and configuration of urban voids, allegories of femininity in city-form ought to be celebrated, not discarded. (shrink)

«Hva er det vi egentlig mener når vi sier, mennesket er dødelig?» spør Woody Allen i boken The Insanity Defence. Han legger til: «Det er åpenbart ikke et kompliment.»1 Jeg tror Woody tar feil her. Vår dødelighet er et kompliment – eller i det minste av det gode – siden livet uten døden ville være katastrofalt. Udødelige liv fører til dyp kjedsomhet, eksistensiell angst og en radikal form for verdinihilistisk tilværelse. Grunnen er at udødeligheten gjør at vi en gang i (...) fremtiden må konfronteres med de radikalt livsfiendtlige stadiene av universets historie. Jeg argumenterer for at dette er en skjebne langt verre enn døden. Konklusjonen blir derfor, med et nikk til Voltaire, at om døden ikke hadde eksistert, hadde vi vært nødt til å finne den opp. (shrink)

Interviewet er lavet i juli 2021. Dets formål er at belyse emner, der er centrale i Celikates’ tænkning, f.eks. den voksende højrefløjspopulisme, migration, voldelige versus ikke-voldelige protester, civil ulydighed og den kritiske filosofis rolle i dag. -/- When Celikates and I sat down digitally in July 2021, the interview’s primary purpose was to examine topics central to Celikates’ thinking, such as the rise of right-wing populism, migration, violent versus non-violent protest, civil disobedience, and the role of critical philosophy today.

Det er min strid at tabellen av intensjonalitet (rasjonalitet, bevissthet, sinn, tanke, språk, personlighet etc.) som har fremtredende her beskriver mer eller mindre nøyaktig, eller i det minste fungerer som en heuristisk for, hvordan vi tenker og oppfører oss, og så omfatter det ikke bare filosofi og psykologi, men alt annet (historie, litteratur, matematikk, politikk etc.). Legg spesielt merke til at intensjonalitet og rasjonalitet som jeg (sammen med Searle, Wittgenstein og andre) ser det, inkluderer både bevisst deliberativspråklig system 2 og (...) bevisstløs automatisert prelinguistic System 1 handlinger eller reflekser. Jeg gir en kritisk undersøkelse av noen av de viktigste funnene fra to av de mest eminente studentene i moderne tid, Ludwig Wittgenstein og John Searle, om den logiske strukturen av intensjonalitet (sinn, språk, bevissthet, oppførsel), tar som utgangspunkt Wittgensteins grunnleggende oppdagelse - at alle virkelig "filosofiske" problemer er de samme - forvirringer om hvordan man bruker språk i en bestemt sammenheng, og så alle løsninger er de samme - ser på hvordan språket kan brukes i sammenheng en sammenheng slik at sannheten forhold (Vilkår for tilfredshet eller COS) er klare. Det grunnleggende problemet er at man kan si noe, men man kan ikke bety (stat klar COS for) noen vilkårlig ytring og mening er bare mulig i en svært spesifikk sammenheng. Jeg analyserer ulike skrifter av og om dem fra det moderne perspektivet til de to tankesystemene (popularisert som "tenker raskt, tenker sakte"), ved hjelp av en ny tabell med intensjonatitet og nye doble systemer nomenklatur. Jeg viser at dette er en mektig heuristisk for å beskrive atferd. Dermed er all oppførsel nært forbundet hvis man tar riktig synspunkt. Den fenomenologiske illusjonen (glemsel en automatisert system 1) er universell og strekker seg ikke bare gjennom filosofi, men gjennom hele livet. Jeg er sikker på at Chomsky, Obama, Zuckerberg og paven ville være vantro hvis fortalt at de lider av det samme problemet som Hegel, Husserl og Heidegger, (eller at de skiller seg bare i grad fra narkotika- og sexavhengige i å være motivert av stimulering av deres frontale kortices ved levering av dopamin (og over 100 andre kjemikalier) via ventral tegmentum og kjernen accumbens), men det er helt klart sant. Mens fenomenologene bare kastet bort mye folks tid, kaster de bort jorden og deres etterkommers fremtid. (shrink)

Det er min strid at tabellen av intensjonalitet (rasjonalitet, bevissthet, sinn, tanke, språk, personlighet etc.) som har fremtredende her beskriver mer eller mindre nøyaktig, eller i det minste fungerer som en heuristisk for, hvordan vi tenker og oppfører oss, og så omfatter det ikke bare filosofi og psykologi, men alt annet (historie, litteratur, matematikk, politikk etc.). Legg spesielt merke til at intensjonalitet og rasjonalitet som jeg (sammen med Searle, Wittgenstein og andre) ser det, inkluderer både bevisst deliberativspråklig system 2 og (...) bevisstløs automatisert prelinguistic System 1 handlinger eller reflekser. Jeg gir en kritisk undersøkelse av noen av de viktigste funnene fra to av de mest eminente studentene i moderne tid, Ludwig Wittgenstein og John Searle, om den logiske strukturen av intensjonalitet (sinn, språk, bevissthet, oppførsel), tar som utgangspunkt Wittgensteins grunnleggende oppdagelse - at alle virkelig "filosofiske" problemer er de samme - forvirringer om hvordan man bruker språk i en bestemt sammenheng, og så alle løsninger er de samme - ser på hvordan språket kan brukes i sammenheng en sammenheng slik at sannheten forhold (Vilkår for tilfredshet eller COS) er klare. Det grunnleggende problemet er at man kan si noe, men man kan ikke bety (stat klar COS for) noen vilkårlig ytring og mening er bare mulig i en svært spesifikk sammenheng. Jeg analyserer ulike skrifter av og om dem fra det moderne perspektivet til de to tankesystemene (popularisert som "tenker raskt, tenker sakte"), ved hjelp av en ny tabell med intensjonatitet og nye doble systemer nomenklatur. Jeg viser at dette er en mektig heuristisk for å beskrive atferd. Dermed er all oppførsel nært forbundet hvis man tar riktig synspunkt. Den fenomenologiske illusjonen (glemsel en automatisert system 1) er universell og strekker seg ikke bare gjennom filosofi, men gjennom hele livet. Jeg er sikker på at Chomsky, Obama, Zuckerberg og paven ville være vantro hvis fortalt at de lider av det samme problemet som Hegel, Husserl og Heidegger, (eller at de skiller seg bare i grad fra narkotika- og sexavhengige i å være motivert av stimulering av deres frontale kortices ved levering av dopamin (og over 100 andre kjemikalier) via ventral tegmentum og kjernen accumbens), men det er helt klart sant. Mens fenomenologene bare kastet bort mye folks tid, kaster de bort jorden og deres etterkommers fremtid. (shrink)

På mange måter er dette en bok som blir utgitt alt for sent. Det er den første antologien av sitt slag, og retter fokus på kvinnelige metafysikere som virket i den tidlige moderne perioden (16. og tidlig 17. århundre). Redaktør Emily Thomas skriver i introduksjonen at til tross for at flere antologier om moderne metafysikk allerede finnes, er kvinnelige filosofer fortsatt underrepresentert og den filosofiske kanon mannsdominert. De ni filosofene som blir omtalt i totalt 13 kapitler var alle originale og (...) velkjente tenkere i sin samtid, men har blitt glemt i filosofihistoriens løp. (shrink)